Mechanism
BPC-157 is a synthetic 15-amino-acid peptide derived from a protective protein found in gastric juice. It promotes angiogenesis via VEGF upregulation, accelerates tendon-to-bone healing, and has demonstrated gastroprotective effects in animal models. It appears to modulate nitric oxide signaling and growth hormone receptor expression.
Indications
Regulatory status
BPC-157 was moved to the FDA 503A Category 2 bulk substances list in 2023, making it ineligible for routine compounding. HHS has signaled intent to review reclassification. Northline does not prescribe Category 2 substances. Members are first notified on any FDA ruling.
References
This fact sheet is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Compounded medications are not FDA-approved. Prescribing decisions are made by a licensed clinician based on individual medical necessity. Not all patients qualify.