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← FormularyTracking · Category 2

Copper Peptide · Tissue Remodeling

GHK-Cu

Skin, connective tissue

Status
On watchlist — not yet prescribable
Get notified on reclassification

Mechanism

GHK-Cu is a naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine) with copper(II). It stimulates collagen and glycosaminoglycan synthesis, activates antioxidant enzymes, and modulates TGF-β signaling. Plasma levels decline significantly with age, correlating with reduced tissue repair capacity.

Indications

→Skin collagen density and elasticity
→Wound healing and scar remodeling
→Hair follicle stimulation
→Anti-inflammatory and antioxidant effects

Regulatory status

GHK-Cu is listed as a Category 2 bulk substance under the FDA 503A framework, making injectable compounding non-compliant. Topical formulations have a different regulatory standing. Northline monitors reclassification.

References

01Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways. BioMed Res Int. 2015.
02FDA 503A Category 2 — injectable compounding ineligible.

This fact sheet is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Compounded medications are not FDA-approved. Prescribing decisions are made by a licensed clinician based on individual medical necessity. Not all patients qualify.