NorthlineHealth
Join
← FormularyTracking · Category 2

Neuropeptide · HPG Axis Modulator

Kisspeptin-10

Hormonal axis

Status
On watchlist — not yet prescribable
Get notified on reclassification

Mechanism

Kisspeptin-10 is the active C-terminal decapeptide of kisspeptin, encoded by the KISS1 gene. It is the primary upstream activator of GnRH neurons, making it a master regulator of the hypothalamic-pituitary-gonadal (HPG) axis. Pulsatile administration stimulates LH and FSH release with downstream testosterone and estrogen effects.

Indications

→Hypogonadotropic hypogonadism
→Fertility and reproductive hormone optimization
→HPG axis evaluation (diagnostic use in research)
→Testosterone and LH support without exogenous hormone

Regulatory status

Kisspeptin-10 is not FDA-approved and is on the 503A Category 2 list. Clinical use is limited to research settings. Northline does not prescribe and monitors reclassification.

References

01Dhillo WS, et al. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab. 2005.
02FDA 503A Category 2 — ineligible for compounding.

This fact sheet is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Compounded medications are not FDA-approved. Prescribing decisions are made by a licensed clinician based on individual medical necessity. Not all patients qualify.