Sermorelin

GH secretagogue · strength, sleep, recovery

Status

Available at launch

Mechanism

Sermorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH). It binds to GHRH receptors in the pituitary, stimulating pulsatile secretion of endogenous growth hormone. Unlike exogenous GH, sermorelin preserves the natural feedback loop — output scales with the pituitary's reserve and is self-limiting.

Indications

→Age-related GH decline

→Lean muscle preservation and recovery

→Sleep quality and slow-wave sleep architecture

→Fat metabolism support alongside GLP-1 protocols

Regulatory status

Sermorelin is FDA-approved (Geref) for pediatric GH deficiency and is eligible for 503A compounding as a bulk substance. Prescribed off-label for adult wellness and anti-aging indications.

References

01Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clin Interv Aging. 2006.

02FDA 503A Bulk Drug Substances List — eligible.

This fact sheet is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Compounded medications are not FDA-approved. Prescribing decisions are made by a licensed clinician based on individual medical necessity. Not all patients qualify.