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← FormularyTracking · Category 2

Peptide · Thymosin Beta-4 Fragment

TB-500

Tissue repair, recovery

Status
On watchlist — not yet prescribable
Get notified on reclassification

Mechanism

TB-500 is a synthetic fragment of thymosin beta-4, a naturally occurring peptide that promotes actin polymerization, cell migration, and angiogenesis. It upregulates cell-building proteins and has demonstrated accelerated wound healing, reduced inflammation, and cardiac protection in preclinical models.

Indications

→Wound and soft-tissue healing
→Muscle and tendon recovery
→Inflammation reduction
→Cardiac tissue repair (preclinical)

Regulatory status

TB-500 (thymosin beta-4 fragment) is on the FDA 503A Category 2 list. Compounding is currently prohibited. Northline tracks reclassification and will notify members of any change in status.

References

01Goldstein AL, Hannappel E, Kleinman HK. Thymosin β4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med. 2005.
02FDA 503A Category 2 — currently ineligible.

This fact sheet is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Compounded medications are not FDA-approved. Prescribing decisions are made by a licensed clinician based on individual medical necessity. Not all patients qualify.